Universität zu Köln

Iden, Sandra ORCID: 0000-0003-2333-9827, van Riel, Wilhelmina E., Schafer, Ronny, Song, Ji-Ying, Hirose, Tomonori ORCID: 0000-0003-2428-0919, Ohno, Shigeo ORCID: 0000-0002-1294-5269 and Collard, John G. (2012). Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis. Cancer Cell, 22 (3). S. 389 - 404. CAMBRIDGE: CELL PRESS. ISSN 1878-3686

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Abstract

Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of growth and survival, since Par3 deletion increases apoptosis and reduces growth in vivo and in vitro. In contrast, Par3-deficient mice are predisposed to formation of keratoacanthomas, cutaneous tumors thought to originate from different cellular origin and frequently observed in humans. Par3 expression is reduced in both mouse and human keratoacanthomas, indicating tumor-suppressive properties of Par3. Our results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Iden, Sandra UNSPECIFIED orcid.org/0000-0003-2333-9827 UNSPECIFIED van Riel, Wilhelmina E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schafer, Ronny UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Ji-Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirose, Tomonori UNSPECIFIED orcid.org/0000-0003-2428-0919 UNSPECIFIED Ohno, Shigeo UNSPECIFIED orcid.org/0000-0002-1294-5269 UNSPECIFIED Collard, John G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-483101
DOI:	10.1016/j.ccr.2012.08.004
Journal or Publication Title:	Cancer Cell
Volume:	22
Number:	3
Page Range:	S. 389 - 404
Date:	2012
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-3686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KINASE-C-IOTA; RAC ACTIVATOR TIAM1; TRANSFORMED GROWTH; EPITHELIAL-CELLS; TRANSGENIC MICE; IN-VIVO; CANCER; COMPLEX; BRAF; INHIBITORS Multiple languages Oncology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48310