Universität zu Köln

Schennach-Wolff, Rebecca, Meyer, Sebastian ORCID: 0000-0002-1791-9449, Seemueller, Florian, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoetter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan ORCID: 0000-0001-8081-7181, Gastpar, Markus, Moeller, Hans-Juergen and Riedel, Michael (2011). Influencing factors and predictors of early improvement in the acute treatment of schizophrenia and schizophrenia spectrum disorder. J. Psychiatr. Res., 45 (12). S. 1639 - 1648. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0022-3956

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Abstract

Background: To examine the influencing factors and predictors of early improvement in schizophrenia patients. Methods: 370 patients suffering from a schizophrenia spectrum disorder were examined within a naturalistic multicenter study. Early improvement was defined as a >= 30% PANSS total score reduction within the first two treatment weeks, response as a >= 50% improvement of the PANSS total score from admission to discharge and remission according to the consensus, remission criteria. Baseline and course-related variables such as positive, negative and depressive symptoms, side effects, functioning and subjective well-being were examined regarding their explanatory value for early improvement. Results: 46% of the patients were identified to be early improvers. Of these, 77% became treatment responder at discharge and 74% achieved the consensus remission criteria. Amongst others, early improvers were significantly more often first-episode patients (p = 0.009), with a significantly shorter duration of current episode (p = 0.024) and a shorter duration of the illness (p = 0.0094). A higher PANSS positive subscore (p = 0.0089), a higher score in the Strauss-Carpenter-Prognostic Scale (SCPS) (p < 0.0001), less extrapyramidal side effects (p = 0.0004) at admission and the development of less extrapyramidal side effects within the first two treatment weeks (p = 0.0013) as well as a duration of current episode of <= 6 months (p = 0.0373) were identified to be significant predictors of early improvement. Conclusion: Early improvement is associated with less illness chronicity and seems to be independent of the type of antipsychotic and the antipsychotic dosage applied. The SCPS was found to be a valuable tool to detect early improvers already at the initiation of antipsychotic treatment. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schennach-Wolff, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Sebastian UNSPECIFIED orcid.org/0000-0002-1791-9449 UNSPECIFIED Seemueller, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauss, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Laux, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Naber, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Lutz G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, Isabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Matthias R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, Stefan UNSPECIFIED orcid.org/0000-0001-8081-7181 UNSPECIFIED Gastpar, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484070
DOI:	10.1016/j.jpsychires.2011.07.014
Journal or Publication Title:	J. Psychiatr. Res.
Volume:	45
Number:	12
Page Range:	S. 1639 - 1648
Date:	2011
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0022-3956
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERMAN RESEARCH NETWORK; RANDOMIZED CONTROLLED-TRIAL; 1ST-EPISODE SCHIZOPHRENIA; TREATMENT RESPONSE; ONSET HYPOTHESIS; FOLLOW-UP; PSYCHOSIS; HALOPERIDOL; REMISSION; ANTIPSYCHOTICS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48407