Chernozem, Roman, V, Romanyuk, Konstantin N., Grubova, Irina, Chernozem, Polina, V, Surmeneva, Maria A., Mukhortova, Yulia R., Wilhelm, Michael ORCID: 0000-0002-4764-6955, Ludwig, Tim ORCID: 0000-0002-3633-805X, Mathur, Sanjay, Kholkin, Andrei L., Neyts, Erik ORCID: 0000-0002-3360-3196, Parakhonskiy, Bogdan ORCID: 0000-0002-6481-3700, Skirtach, Andre G. and Surmenev, Roman A. (2021). Enhanced piezoresponse and surface electric potential of hybrid biodegradable polyhydroxybutyrate scaffolds functionalized with reduced graphene oxide for tissue engineering. Nano Energy, 89. AMSTERDAM: ELSEVIER. ISSN 2211-3282

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Abstract

Piezoelectricity is considered to be one of the key functionalities in biomaterials to boost bone tissue regeneration, however, integrating biocompatibility, biodegradability and 3D structure with pronounced piezoresponse remains a material challenge. Herein, novel hybrid biocompatible 3D scaffolds based on biodegradable poly(3-hydroxybutyrate) (PHB) and reduced graphene oxide (rGO) flakes have been developed. Nanoscale insights revealed a more homogenous distribution and superior surface potential values of PHB fibers (33 +/- 29 mV) with increasing rGO content up to 1.0 wt% (314 +/- 31 mV). The maximum effective piezoresponse was detected at 0.7 wt% rGO content, demonstrating 2.5 and 1.7 times higher out-of-plane and in-plane values, respectively, than that for pure PHB fibers. The rGO addition led to enhanced zigzag chain formation between paired lamellae in PHB fibers. In contrast, a further increase in rGO content reduced the alpha-crystal size and prevented zigzag chain conformation. A corresponding model explaining structural and molecular changes caused by rGO addition in electrospun PHB fibers is proposed. In addition, finite element analysis revealed a negligible vertical piezoresponse compared to lateral piezoresponse in uniaxially oriented PHB fibers based on alpha-phase (P2(1)2(1)2(1) space group). Thus, the present study demonstrates promising results for the development of biodegradable hybrid 3D scaffolds with an enhanced piezoresponse for various tissue engineering applications.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chernozem, Roman, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romanyuk, Konstantin N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grubova, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chernozem, Polina, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surmeneva, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mukhortova, Yulia R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilhelm, MichaelUNSPECIFIEDorcid.org/0000-0002-4764-6955UNSPECIFIED
Ludwig, TimUNSPECIFIEDorcid.org/0000-0002-3633-805XUNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kholkin, Andrei L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neyts, ErikUNSPECIFIEDorcid.org/0000-0002-3360-3196UNSPECIFIED
Parakhonskiy, BogdanUNSPECIFIEDorcid.org/0000-0002-6481-3700UNSPECIFIED
Skirtach, Andre G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surmenev, Roman A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-593092
DOI: 10.1016/j.nanoen.2021.106473
Journal or Publication Title: Nano Energy
Volume: 89
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 2211-3282
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PIEZOELECTRIC PROPERTIES; ULTRASOFT PSEUDOPOTENTIALS; CHEMICAL-REDUCTION; RAMAN-SPECTROSCOPY; ELASTIC PROPERTIES; POLY(3-HYDROXYBUTYRATE); CRYSTALLINITY; BIOMATERIALS; DEGRADATION; COMPOSITESMultiple languages
Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, AppliedMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59309

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