Stuckenschneider, Tim ORCID: 0000-0002-0972-4377, Sanders, Marit L., Devenney, Kate E., Aaronson, Justine A., Abeln, Vera, Claassen, Jurgen A. H. R., Guinan, Emer, Lawlor, Brian, Meeusen, Romain, Montag, Christian ORCID: 0000-0001-8112-0837, Olde Rikkert, Marcel G. M., Polidori, M. Cristina, Reuter, Martin, Schulz, Ralf-Joachim, Vogt, Tobias, Weber, Bernd ORCID: 0000-0002-7811-9605, Kessels, Roy P. C. and Schneider, Stefan (2021). NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment-A Multicenter Randomized Controlled Trial. Front. Aging Neurosci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(-0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [-1.76 (-3.39, -0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO(2)peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stuckenschneider, TimUNSPECIFIEDorcid.org/0000-0002-0972-4377UNSPECIFIED
Sanders, Marit L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devenney, Kate E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaronson, Justine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abeln, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claassen, Jurgen A. H. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guinan, EmerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawlor, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meeusen, RomainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montag, ChristianUNSPECIFIEDorcid.org/0000-0001-8112-0837UNSPECIFIED
Olde Rikkert, Marcel G. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polidori, M. CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuter, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Ralf-JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogt, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, BerndUNSPECIFIEDorcid.org/0000-0002-7811-9605UNSPECIFIED
Kessels, Roy P. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-599838
DOI: 10.3389/fnagi.2020.621947
Journal or Publication Title: Front. Aging Neurosci.
Volume: 12
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1663-4365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS ASSOCIATION WORKGROUPS; CARDIORESPIRATORY FITNESS; PHYSICAL-EXERCISE; OLDER-ADULTS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DEMENTIA; DISEASE; OUTCOMES; RECOMMENDATIONSMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59983

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